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Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells

The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallography and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1H-indole derivatives that display high potential and specificity t...

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Detalles Bibliográficos
Autores principales:	Song, Peilu, Zhao, Fan, Li, Dahong, Qu, Jiqiang, Yao, Miao, Su, Yuan, Wang, Hanxun, Zhou, Miaomiao, Wang, Yujie, Gao, Yinli, Li, Feng, Zhao, Dongmei, Zhang, Fengjiao, Rao, Yu, Xia, Mingyu, Li, Haitao, Wang, Jian, Cheng, Maosheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214071/ https://www.ncbi.nlm.nih.gov/pubmed/35755272 http://dx.doi.org/10.1016/j.apsb.2022.02.029

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