Cancer cells resist antibody-mediated destruction by neutrophils through activation of the exocyst complex

BACKGROUND: Neutrophils kill antibody-opsonized tumor cells using trogocytosis, a unique mechanism of destruction of the target plasma. This previously unknown cytotoxic process of neutrophils is dependent on antibody opsonization, Fcγ receptors and CD11b/CD18 integrins. Here, we demonstrate that tu...

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Detalles Bibliográficos
Autores principales: van Rees, Dieke J, Bouti, Panagiota, Klein, Bart, Verkuijlen, Paul J H, van Houdt, Michel, Schornagel, Karin, Tool, Anton T J, Venet, David, Sotiriou, Christos, El-Abed, Sarra, Izquierdo, Miguel, Guillaume, Sébastien, Saura, Cristina, Di Cosimo, Serena, Huober, Jens, Roylance, Rebecca, Kim, Sung-Bae, Kuijpers, Taco W, van Bruggen, Robin, K van den Berg, Timo, Matlung, Hanke L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214435/
https://www.ncbi.nlm.nih.gov/pubmed/35728876
http://dx.doi.org/10.1136/jitc-2022-004820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214435/
https://www.ncbi.nlm.nih.gov/pubmed/35728876
http://dx.doi.org/10.1136/jitc-2022-004820

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