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Cancer cells resist antibody-mediated destruction by neutrophils through activation of the exocyst complex
BACKGROUND: Neutrophils kill antibody-opsonized tumor cells using trogocytosis, a unique mechanism of destruction of the target plasma. This previously unknown cytotoxic process of neutrophils is dependent on antibody opsonization, Fcγ receptors and CD11b/CD18 integrins. Here, we demonstrate that tu...
Autores principales: | van Rees, Dieke J, Bouti, Panagiota, Klein, Bart, Verkuijlen, Paul J H, van Houdt, Michel, Schornagel, Karin, Tool, Anton T J, Venet, David, Sotiriou, Christos, El-Abed, Sarra, Izquierdo, Miguel, Guillaume, Sébastien, Saura, Cristina, Di Cosimo, Serena, Huober, Jens, Roylance, Rebecca, Kim, Sung-Bae, Kuijpers, Taco W, van Bruggen, Robin, K van den Berg, Timo, Matlung, Hanke L |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214435/ https://www.ncbi.nlm.nih.gov/pubmed/35728876 http://dx.doi.org/10.1136/jitc-2022-004820 |
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