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Proteo-genetic analysis reveals clear hierarchy of ESX-1 secretion in Mycobacterium marinum

The ESX-1 (ESAT-6-system-1) system and the protein substrates it transports are essential for mycobacterial pathogenesis. The precise ways that ESX-1 substrates contribute to virulence remains unknown. Several known ESX-1 substrates are also required for the secretion of other proteins. We used a pr...

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Detalles Bibliográficos
Autores principales: Cronin, Rachel M., Ferrell, Micah J., Cahir, Clare W., Champion, Matthew M., Champion, Patricia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214503/
https://www.ncbi.nlm.nih.gov/pubmed/35671426
http://dx.doi.org/10.1073/pnas.2123100119