Myeloid caspase-8 restricts RIPK3-dependent proinflammatory IL-1β production and CD4 T cell activation in autoimmune demyelination

Caspase-8 functions at the crossroad of programmed cell death and inflammation. Here, using genetic approaches and the experimental autoimmune encephalomyelitis model of inflammatory demyelination, we identified a negative regulatory pathway for caspase-8 in infiltrated macrophages whereby it functi...

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Detalles Bibliográficos
Autores principales: Kim, Sunja, Lu, Hsueh Chung, Steelman, Andrew J., Li, Jianrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214530/
https://www.ncbi.nlm.nih.gov/pubmed/35671429
http://dx.doi.org/10.1073/pnas.2117636119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214530/
https://www.ncbi.nlm.nih.gov/pubmed/35671429
http://dx.doi.org/10.1073/pnas.2117636119

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