Cargando…

N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth

Despite the evidences of elevated expression of Mer tyrosine kinase (MerTK) in multiple human cancers, mechanisms underlying the oncogenic roles of MerTK in hepatocellular carcinoma (HCC) remains undefined. We explored the functional effects of MerTK and N-Glycosylated MerTK on HCC cell survival and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yongzhang, Lan, Linhua, Li, Yujie, Lu, Jing, He, Lipeng, Deng, Yao, Fei, Mingming, Lu, Jun-Wan, Shangguan, Fugen, Lu, Ju-Ping, Wang, Jiaxin, Wu, Liang, Huang, Kate, Lu, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214875/ https://www.ncbi.nlm.nih.gov/pubmed/35728303 http://dx.doi.org/10.1016/j.redox.2022.102366

Ejemplares similares

MerTK inhibition by RXDX-106 in MerTK activated gastric cancer cell lines
por: Kim, Jung Eun, et al.
Publicado: (2017)

Harnessing MerTK agonism for targeted therapeutics
por: Kedage, Vivekananda, et al.
Publicado: (2019)

MerTK, a risk factor for NASH fibrosis
por: Wang, Xiaobo, et al.
Publicado: (2020)

MerTK is required for apoptotic cell–induced T cell tolerance
por: Wallet, Mark A., et al.
Publicado: (2008)

MerTK is a novel therapeutic target in gastric cancer
por: Yi, Jun Ho, et al.
Publicado: (2015)

The Synthesis and Initial Evaluation of MerTK Targeted PET Agents
por: Wang, Li, et al.
Publicado: (2022)

MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme
por: Knubel, Kristina H., et al.
Publicado: (2014)

High Glucose Impairs Expression and Activation of MerTK in ARPE-19 Cells
por: Puddu, Alessandra, et al.
Publicado: (2022)

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
por: Triantafyllou, Evangelos, et al.
Publicado: (2018)

MerTK-mediated regulation of myelin phagocytosis by macrophages generated from patients with MS
por: Healy, Luke M., et al.
Publicado: (2017)

Microglia Inhibition Delays Retinal Degeneration Due to MerTK Phagocytosis Receptor Deficiency
por: Lew, Deborah S., et al.
Publicado: (2020)

Targeted Phagocytosis Induction for Cancer Immunotherapy via Bispecific MerTK-Engaging Antibodies
por: Carrara, Stefania C., et al.
Publicado: (2022)

Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemia
por: Brandao, L N, et al.
Publicado: (2013)

Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment
por: Myers, Kayla V., et al.
Publicado: (2019)

Targeting MerTK decreases efferocytosis and increases anti-tumor immune infiltrate in prostate cancer
por: Myers Chen, Kayla V., et al.
Publicado: (2023)

Gsk3β regulates the resolution of liver ischemia/reperfusion injury via MerTK
por: Zhang, Hanwen, et al.
Publicado: (2023)

Gas6/MerTK signaling is negatively regulated by NF-κB and supports lung carcinogenesis
por: Novitskiy, Sergey V., et al.
Publicado: (2019)

Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators
por: Pastore, Mirella, et al.
Publicado: (2022)

Axl and MerTK receptor tyrosine kinases maintain human macrophage efferocytic capacity in the presence of viral triggers
por: Grabiec, Aleksander M, et al.
Publicado: (2018)

Study of the Role of the Tyrosine Kinase Receptor MerTK in the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats
por: Pelé, Thomas, et al.
Publicado: (2021)

Dual targeting of TAM receptors Tyro3, Axl, and MerTK: Role in tumors and the tumor immune microenvironment
por: Wang, Kai-Hung, et al.
Publicado: (2020)

mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition
por: Xue, Gongda, et al.
Publicado: (2017)

Tyrosine Kinase Receptors Axl and MerTK Mediate the Beneficial Effect of Electroacupuncture in a Cuprizone-Induced Demyelinating Model
por: Zou, Zaofeng, et al.
Publicado: (2020)

Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development
por: Park, Tae Hyun, et al.
Publicado: (2020)

MerTK Expression and ERK Activation Are Essential for the Functional Maturation of Osteopontin‐Producing Reparative Macrophages After Myocardial Infarction
por: Shirakawa, Kohsuke, et al.
Publicado: (2020)

Differential polarization and the expression of efferocytosis receptor MerTK on M1 and M2 macrophages isolated from coronary artery disease patients
por: Mohd Idrus, Fatin Najiah, et al.
Publicado: (2021)

Expression of TAM-R in Human Immune Cells and Unique Regulatory Function of MerTK in IL-10 Production by Tolerogenic DC
por: Giroud, Paul, et al.
Publicado: (2020)

Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK
por: Mao, Yingyu, et al.
Publicado: (2021)

Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages
por: Jhang, Kyoung A., et al.
Publicado: (2018)

MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression
por: Lin, Jinti, et al.
Publicado: (2022)

Mer Tyrosine Kinase (MERTK) modulates liver fibrosis progression and hepatocellular carcinoma development
por: Pipitone, Rosaria Maria, et al.
Publicado: (2022)

Ginsenoside Rg3 Attenuates Lipopolysaccharide-Induced Acute Lung Injury via MerTK-Dependent Activation of the PI3K/AKT/mTOR Pathway
por: Yang, Jing, et al.
Publicado: (2018)

KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway
por: Du, Wenwen, et al.
Publicado: (2020)

The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization
por: Zizzo, Gaetano, et al.
Publicado: (2015)

RUNX2 and LAMC2: promising pancreatic cancer biomarkers identified by an integrative data mining of pancreatic adenocarcinoma tissues
por: Jin, Guihua, et al.
Publicado: (2021)

LonP1 Links Mitochondria–ER Interaction to Regulate Heart Function
por: Li, Yujie, et al.
Publicado: (2023)

Sex hormone-binding globulin impedes hepatocellular carcinoma growth via MERTK regulation
por: Lee, Sang R., et al.
Publicado: (2021)

Elevated p53 expression levels correlate with tumor progression and poor prognosis in patients exhibiting esophageal squamous cell carcinoma
por: HUANG, KATE, et al.
Publicado: (2014)

Mertk Deficiency Affects Macrophage Directional Migration via Disruption of Cytoskeletal Organization
por: Tang, Yong, et al.
Publicado: (2015)

A Novel Mechanism of Cannabidiol in Suppressing Hepatocellular Carcinoma by Inducing GSDME Dependent Pyroptosis
por: Shangguan, Fugen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5t19dmgkms61gaq0dea1lunquj