Cryo-EM structure of acylpeptide hydrolase reveals substrate selection by multimerization and a multi-state serine-protease triad

The first structure of tetrameric mammalian acylaminoacyl peptidase, an enzyme that functions as an upstream regulator of the proteasome through the removal of terminal N-acetylated residues from its protein substrates, was determined by cryo-EM and further elucidated by MD simulations. Self-associa...

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Detalles Bibliográficos
Autores principales: Kiss-Szemán, Anna J., Stráner, Pál, Jákli, Imre, Hosogi, Naoki, Harmat, Veronika, Menyhárd, Dóra K., Perczel, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214879/
https://www.ncbi.nlm.nih.gov/pubmed/35799812
http://dx.doi.org/10.1039/d2sc02276a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214879/
https://www.ncbi.nlm.nih.gov/pubmed/35799812
http://dx.doi.org/10.1039/d2sc02276a

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