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Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes
Protein ubiquitination is an essential process that rapidly regulates protein synthesis, function, and fate in dynamic environments. Within its non-proteolytic functions, we showed that K63-linked polyubiquitinated conjugates heavily accumulate in yeast cells exposed to oxidative stress, stalling ri...
Autores principales: | Simões, Vanessa, Cizubu, Blanche K., Harley, Lana, Zhou, Ye, Pajak, Joshua, Snyder, Nathan A., Bouvette, Jonathan, Borgnia, Mario J., Arya, Gaurav, Bartesaghi, Alberto, Silva, Gustavo M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9215706/ https://www.ncbi.nlm.nih.gov/pubmed/35613580 http://dx.doi.org/10.1016/j.celrep.2022.110860 |
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