Cargando…
Quercetin and luteolin are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global health pandemic. Among the viral proteins, RNA-dependent RNA polymerase (RdRp) is responsible for viral genome replication and has emerged as one of the most promising targets for pharmacological intervention ag...
Autores principales: | Munafò, Federico, Donati, Elisa, Brindani, Nicoletta, Ottonello, Giuliana, Armirotti, Andrea, De Vivo, Marco |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216299/ https://www.ncbi.nlm.nih.gov/pubmed/35732785 http://dx.doi.org/10.1038/s41598-022-14664-2 |
Ejemplares similares
-
Design, synthesis, docking, and biochemical characterization of non-nucleoside SARS-CoV-2 RdRp inhibitors
por: Brindani, Nicoletta, et al.
Publicado: (2023) -
Design, Synthesis,
Dynamic Docking, Biochemical Characterization,
and in Vivo Pharmacokinetics Studies of Novel Topoisomerase
II Poisons with Promising Antiproliferative Activity
por: Arencibia, Jose M., et al.
Publicado: (2020) -
Rutin Is a Low Micromolar Inhibitor of SARS-CoV-2 Main Protease 3CLpro: Implications for Drug Design of Quercetin Analogs
por: Rizzuti, Bruno, et al.
Publicado: (2021) -
Design, Synthesis, In Vitro and In Vivo Characterization of Selective NKCC1 Inhibitors for
the Treatment of Core Symptoms in Down Syndrome
por: Borgogno, Marco, et al.
Publicado: (2021) -
Synergy and Mode of Action of Ceftazidime plus Quercetin or Luteolin on Streptococcus pyogenes
por: Siriwong, Supatcharee, et al.
Publicado: (2015)