Design and synthesis of Nrf2-derived hydrocarbon stapled peptides for the disruption of protein-DNA-interactions

Misregulation and mutations of the transcription factor Nrf2 are involved in the development of a variety of human diseases. In this study, we employed the technology of stapled peptides to address a protein-DNA-complex and designed a set of Nrf2-based derivatives. Varying the length and position of...

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Detalles Bibliográficos
Autores principales: Wiedemann, Bianca, Kamps, Dominic, Depta, Laura, Weisner, Jörn, Cvetreznik, Jana, Tomassi, Stefano, Gentz, Sascha, Hoffmann, Jan-Erik, Müller, Matthias P., Koch, Oliver, Dehmelt, Leif, Rauh, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216541/
https://www.ncbi.nlm.nih.gov/pubmed/35731722
http://dx.doi.org/10.1371/journal.pone.0267651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216541/
https://www.ncbi.nlm.nih.gov/pubmed/35731722
http://dx.doi.org/10.1371/journal.pone.0267651

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