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Inhibition of histone H3-H4 chaperone pathways rescues C. elegans sterility by H2B loss
Oncohistone mutations are crucial drivers for tumorigenesis, but how a living organism governs the loss-of-function oncohistone remains unclear. We generated a histone H2B triple knockout (3KO) strain in Caenorhabditis elegans, which decreased the embryonic H2B, disrupted cell divisions, and caused...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216614/ https://www.ncbi.nlm.nih.gov/pubmed/35679337 http://dx.doi.org/10.1371/journal.pgen.1010223 |