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Inhibition of histone H3-H4 chaperone pathways rescues C. elegans sterility by H2B loss

Oncohistone mutations are crucial drivers for tumorigenesis, but how a living organism governs the loss-of-function oncohistone remains unclear. We generated a histone H2B triple knockout (3KO) strain in Caenorhabditis elegans, which decreased the embryonic H2B, disrupted cell divisions, and caused...

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Detalles Bibliográficos
Autores principales:	Zhao, Ruixue, Zhu, Zhiwen, Geng, Ruxu, Jiang, Xuguang, Li, Wei, Ou, Guangshuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216614/ https://www.ncbi.nlm.nih.gov/pubmed/35679337 http://dx.doi.org/10.1371/journal.pgen.1010223

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