Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers

Protein folding homeostasis in the endoplasmic reticulum (ER) is regulated by a signaling network, termed the unfolded protein response (UPR). Inositol-requiring enzyme 1 (IRE1) is an ER membrane-resident kinase/RNase that mediates signal transmission in the most evolutionarily conserved branch of t...

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Detalles Bibliográficos
Autores principales: Belyy, Vladislav, Zuazo-Gaztelu, Iratxe, Alamban, Andrew, Ashkenazi, Avi, Walter, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217129/
https://www.ncbi.nlm.nih.gov/pubmed/35730415
http://dx.doi.org/10.7554/eLife.74342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217129/
https://www.ncbi.nlm.nih.gov/pubmed/35730415
http://dx.doi.org/10.7554/eLife.74342

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