Live imaging of the co-translational recruitment of XBP1 mRNA to the ER and its processing by diffuse, non-polarized IRE1α

Endoplasmic reticulum (ER) to nucleus homeostatic signaling, known as the unfolded protein response (UPR), relies on the non-canonical splicing of XBP1 mRNA. The molecular switch that initiates splicing is the oligomerization of the ER stress sensor and UPR endonuclease IRE1α (inositol-requiring enz...

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Detalles Bibliográficos
Autores principales: Gómez-Puerta, Silvia, Ferrero, Roberto, Hochstoeger, Tobias, Zubiri, Ivan, Chao, Jeffrey, Aragón, Tomás, Voigt, Franka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217131/
https://www.ncbi.nlm.nih.gov/pubmed/35730412
http://dx.doi.org/10.7554/eLife.75580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217131/
https://www.ncbi.nlm.nih.gov/pubmed/35730412
http://dx.doi.org/10.7554/eLife.75580

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