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Histone deacetylase 4 reverses cellular senescence via DDIT4 in dermal fibroblasts

Histone deacetylases (HDACs) remove acetyl groups from lysine chains on histones and other proteins and play a crucial role in epigenetic regulation and aging. Previously, we demonstrated that HDAC4 is consistently downregulated in aged and ultraviolet (UV)-irradiated human skin in vivo. Cellular se...

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Detalles Bibliográficos
Autores principales: Lee, Yuri, Song, Min Ji, Park, Ji Hwan, Shin, Mi Hee, Kim, Min-Kyoung, Hwang, Daehee, Lee, Dong Hun, Chung, Jin Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217707/
https://www.ncbi.nlm.nih.gov/pubmed/35680564
http://dx.doi.org/10.18632/aging.204118