Specific and sensitive GC–MS analysis of hypusine, N(ε)-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study

Hypusination is a unique two-step enzymatic post-translational modification of the N(ε)-amino group of lysine-50 of the eukaryotic initiation factor 5A (eIF5A). We developed a specific and sensitive gas chromatography–mass spectrometry (GC–MS) method for the measurement of biological hypusine (Hyp),...

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Detalles Bibliográficos
Autores principales: Baskal, Svetlana, Kaiser, Annette, Mels, Catharina, Kruger, Ruan, Tsikas, Dimitrios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217869/
https://www.ncbi.nlm.nih.gov/pubmed/35243537
http://dx.doi.org/10.1007/s00726-022-03142-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217869/
https://www.ncbi.nlm.nih.gov/pubmed/35243537
http://dx.doi.org/10.1007/s00726-022-03142-8

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