In vitro–in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans

New approach methodologies predicting human cardiotoxicity are of interest to support or even replace in vivo-based drug safety testing. The present study presents an in vitro–in silico approach to predict the effect of inter-individual and inter-ethnic kinetic variations in the cardiotoxicity of R-...

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Detalles Bibliográficos
Autores principales: Shi, Miaoying, Dong, Yumeng, Bouwmeester, Hans, Rietjens, Ivonne M. C. M., Strikwold, Marije
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Organ Toxicity and Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217890/
https://www.ncbi.nlm.nih.gov/pubmed/35604418
http://dx.doi.org/10.1007/s00204-022-03309-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217890/
https://www.ncbi.nlm.nih.gov/pubmed/35604418
http://dx.doi.org/10.1007/s00204-022-03309-y

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