Maternal Folic Acid Supplementation, Dietary Folate Intake, and Low Birth Weight: A Birth Cohort Study

OBJECTIVES: To investigate the independent and collective effects of maternal folic acid supplementation or dietary folate intake on the risk of low birth weight (LBW), and to further comprehensively examine the joint associations of folic acid supplementation and dietary folate intake with LBW by v...

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Autores principales: Yang, Liping, Wang, Wenjuan, Mao, Baohong, Qiu, Jie, Guo, Huaqi, Yi, Bin, He, Xiaochun, Lin, Xiaojuan, Lv, Ling, Xu, Xiaoying, Liu, Qing, Cao, Yongchun, Chen, Yiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218084/
https://www.ncbi.nlm.nih.gov/pubmed/35757618
http://dx.doi.org/10.3389/fpubh.2022.844150
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author Yang, Liping
Wang, Wenjuan
Mao, Baohong
Qiu, Jie
Guo, Huaqi
Yi, Bin
He, Xiaochun
Lin, Xiaojuan
Lv, Ling
Xu, Xiaoying
Liu, Qing
Cao, Yongchun
Chen, Yiming
author_facet Yang, Liping
Wang, Wenjuan
Mao, Baohong
Qiu, Jie
Guo, Huaqi
Yi, Bin
He, Xiaochun
Lin, Xiaojuan
Lv, Ling
Xu, Xiaoying
Liu, Qing
Cao, Yongchun
Chen, Yiming
author_sort Yang, Liping
collection PubMed
description OBJECTIVES: To investigate the independent and collective effects of maternal folic acid supplementation or dietary folate intake on the risk of low birth weight (LBW), and to further comprehensively examine the joint associations of folic acid supplementation and dietary folate intake with LBW by various clinical subtypes. DESIGN: Participants were recruited from Gansu Provincial Maternity and Child Care Hospital. A standardized and structured questionnaire was distributed to collect demographic factors, reproductive and medical history, occupational and residential history, physical activity, and diet. Data on pregnancy-related complications and birth outcomes were extracted from medical records. Unconditional logistic regression models were used to estimate the odds ratio (OR) and 95% confidence interval (95% CI) for single and joint associations of folic acid supplementation and dietary folate intake with LBW. SETTING: A birth cohort data analysis using the 2010–2012 Gansu Provincial Maternity and Child Care Hospital in Lanzhou, China. PARTICIPANTS: In total, 9,231 pregnant women and their children were enrolled in the study. RESULTS: Compared with non-users, folic acid supplementation was associated with a reduced risk of LBW (OR: 0.80, 95% CI: 0.66–0.97), and the reduced risk was mainly seen for term-LBW (OR: 0.59, 95% CI: 0.41–0.85), and multiparous-LBW (OR: 0.72, 95% CI: 0.54–0.94). There were no significant associations between dietary folate intake and LBW, and there was no interaction between folic acid supplement and dietary folate intake on LBW. CONCLUSIONS: Our study results indicated that folic acid supplementation was associated with a reduced risk of LBW, and there was no interaction between folic acid supplements and dietary folate intake on LBW.
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spelling pubmed-92180842022-06-24 Maternal Folic Acid Supplementation, Dietary Folate Intake, and Low Birth Weight: A Birth Cohort Study Yang, Liping Wang, Wenjuan Mao, Baohong Qiu, Jie Guo, Huaqi Yi, Bin He, Xiaochun Lin, Xiaojuan Lv, Ling Xu, Xiaoying Liu, Qing Cao, Yongchun Chen, Yiming Front Public Health Public Health OBJECTIVES: To investigate the independent and collective effects of maternal folic acid supplementation or dietary folate intake on the risk of low birth weight (LBW), and to further comprehensively examine the joint associations of folic acid supplementation and dietary folate intake with LBW by various clinical subtypes. DESIGN: Participants were recruited from Gansu Provincial Maternity and Child Care Hospital. A standardized and structured questionnaire was distributed to collect demographic factors, reproductive and medical history, occupational and residential history, physical activity, and diet. Data on pregnancy-related complications and birth outcomes were extracted from medical records. Unconditional logistic regression models were used to estimate the odds ratio (OR) and 95% confidence interval (95% CI) for single and joint associations of folic acid supplementation and dietary folate intake with LBW. SETTING: A birth cohort data analysis using the 2010–2012 Gansu Provincial Maternity and Child Care Hospital in Lanzhou, China. PARTICIPANTS: In total, 9,231 pregnant women and their children were enrolled in the study. RESULTS: Compared with non-users, folic acid supplementation was associated with a reduced risk of LBW (OR: 0.80, 95% CI: 0.66–0.97), and the reduced risk was mainly seen for term-LBW (OR: 0.59, 95% CI: 0.41–0.85), and multiparous-LBW (OR: 0.72, 95% CI: 0.54–0.94). There were no significant associations between dietary folate intake and LBW, and there was no interaction between folic acid supplement and dietary folate intake on LBW. CONCLUSIONS: Our study results indicated that folic acid supplementation was associated with a reduced risk of LBW, and there was no interaction between folic acid supplements and dietary folate intake on LBW. Frontiers Media S.A. 2022-06-09 /pmc/articles/PMC9218084/ /pubmed/35757618 http://dx.doi.org/10.3389/fpubh.2022.844150 Text en Copyright © 2022 Yang, Wang, Mao, Qiu, Guo, Yi, He, Lin, Lv, Xu, Liu, Cao and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Yang, Liping
Wang, Wenjuan
Mao, Baohong
Qiu, Jie
Guo, Huaqi
Yi, Bin
He, Xiaochun
Lin, Xiaojuan
Lv, Ling
Xu, Xiaoying
Liu, Qing
Cao, Yongchun
Chen, Yiming
Maternal Folic Acid Supplementation, Dietary Folate Intake, and Low Birth Weight: A Birth Cohort Study
title Maternal Folic Acid Supplementation, Dietary Folate Intake, and Low Birth Weight: A Birth Cohort Study
title_full Maternal Folic Acid Supplementation, Dietary Folate Intake, and Low Birth Weight: A Birth Cohort Study
title_fullStr Maternal Folic Acid Supplementation, Dietary Folate Intake, and Low Birth Weight: A Birth Cohort Study
title_full_unstemmed Maternal Folic Acid Supplementation, Dietary Folate Intake, and Low Birth Weight: A Birth Cohort Study
title_short Maternal Folic Acid Supplementation, Dietary Folate Intake, and Low Birth Weight: A Birth Cohort Study
title_sort maternal folic acid supplementation, dietary folate intake, and low birth weight: a birth cohort study
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218084/
https://www.ncbi.nlm.nih.gov/pubmed/35757618
http://dx.doi.org/10.3389/fpubh.2022.844150
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