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Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently
One of the hallmarks of cancer cells is their ability to evade apoptosis, which confers survival advantages and resistance to anti-cancer drugs. Cancers often exhibit overexpression of anti-apoptotic BCL-2 proteins, the loss of which triggers apoptosis. In particular, the inhibition of both BCL-xL a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218148/ https://www.ncbi.nlm.nih.gov/pubmed/35782728 http://dx.doi.org/10.1016/j.csbj.2022.06.021 |