Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently

One of the hallmarks of cancer cells is their ability to evade apoptosis, which confers survival advantages and resistance to anti-cancer drugs. Cancers often exhibit overexpression of anti-apoptotic BCL-2 proteins, the loss of which triggers apoptosis. In particular, the inhibition of both BCL-xL a...

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Detalles Bibliográficos
Autores principales: Kim, Seonghoon, Park, Hee-Sung, Oh, Byung-Ha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218148/
https://www.ncbi.nlm.nih.gov/pubmed/35782728
http://dx.doi.org/10.1016/j.csbj.2022.06.021

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