Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A

The treatment of colorectal cancer (CRC) with FOLFOX shows some efficacy, but these tumors quickly develop resistance to this treatment. We have observed increased phosphorylation of AKT1/mTOR/4EBP1 and levels of p21 in FOLFOX-resistant CRC cells. We have identified a small molecule, NSC49L, that st...

Descripción completa

Detalles Bibliográficos
Autores principales: Narayan, Satya, Raza, Asif, Mahmud, Iqbal, Koo, Nayeong, Garrett, Timothy J., Law, Mary E., Law, Brian K., Sharma, Arun K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218363/
https://www.ncbi.nlm.nih.gov/pubmed/35754740
http://dx.doi.org/10.1016/j.isci.2022.104518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218363/
https://www.ncbi.nlm.nih.gov/pubmed/35754740
http://dx.doi.org/10.1016/j.isci.2022.104518

Ejemplares similares