Structural basis for binding diversity of acetyltransferase p300 to the nucleosome

p300 is a human acetyltransferase that associates with chromatin and mediates vital cellular processes. We now report the cryo-electron microscopy structures of the p300 catalytic core in complex with the nucleosome core particle (NCP). In the most resolved structure, the HAT domain and bromodomain...

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Detalles Bibliográficos
Autores principales: Hatazawa, Suguru, Liu, Jiuyang, Takizawa, Yoshimasa, Zandian, Mohamad, Negishi, Lumi, Kutateladze, Tatiana G., Kurumizaka, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218434/
https://www.ncbi.nlm.nih.gov/pubmed/35754730
http://dx.doi.org/10.1016/j.isci.2022.104563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218434/
https://www.ncbi.nlm.nih.gov/pubmed/35754730
http://dx.doi.org/10.1016/j.isci.2022.104563

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