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Organoid-derived intestinal epithelial cells are a suitable model for preclinical toxicology and pharmacokinetic studies
Intestinal organoids are physiologically relevant tools used for cellular models. However, the suitability of organoids to examine biological functions over existing established cell lines lacks sufficient evidence. Cytochrome P450 3A4 (CYP3A4) induction by pregnane X receptor ligands, glucose uptak...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218437/ https://www.ncbi.nlm.nih.gov/pubmed/35754737 http://dx.doi.org/10.1016/j.isci.2022.104542 |