Aged Callus Skeletal Stem/Progenitor Cells Contain an Inflammatory Osteogenic Population With Increased IRF and NF-κB Pathways and Reduced Osteogenic Potential

Skeletal stem/progenitor cells (SSPCs) are critical for fracture repair by providing osteo-chondro precursors in the callus, which is impaired in aging. However, the molecular signatures of callus SSPCs during aging are not known. Herein, we performed single-cell RNA sequencing on 11,957 CD45(-)CD31...

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Detalles Bibliográficos
Autores principales: Lin, X., Zhang, H., Liu, J., Wu, C L., McDavid, A., Boyce, B. F., Xing, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218815/
https://www.ncbi.nlm.nih.gov/pubmed/35755815
http://dx.doi.org/10.3389/fmolb.2022.806528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9218815/
https://www.ncbi.nlm.nih.gov/pubmed/35755815
http://dx.doi.org/10.3389/fmolb.2022.806528

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