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C(sp(3))-Arylation by Conformationally Accelerated Intramolecular Nucleophilic Aromatic Substitution (S(N)Ar)

[Image: see text] The asymmetric synthesis of heavily substituted benzylic stereogenic centers, prevalent in natural products, therapeutics, agrochemicals, and catalysts, is an ongoing challenge. In this Account, we outline our contribution to this endeavor, describing our discovery of a series of n...

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Detalles Bibliográficos
Autores principales: Wales, Steven M., Saunthwal, Rakesh K., Clayden, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219115/
https://www.ncbi.nlm.nih.gov/pubmed/35620846
http://dx.doi.org/10.1021/acs.accounts.2c00184