Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro

SIMPLE SUMMARY: Despite their documented antitumor effects, thienopyrazole-based compounds remain an underexplored class of molecules. In this study, a screening of 2000 novel molecules revealed a unique thienopyrazole derivative, Tpz-1, that elicited potent and selective programmed cell death in hu...

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Detalles Bibliográficos
Autores principales: Hess, Jessica D., Macias, Luca H., Gutierrez, Denisse A., Moran-Santibanez, Karla, Contreras, Lisett, Medina, Stephanie, Villanueva, Paulina J., Kirken, Robert A., Varela-Ramirez, Armando, Penichet, Manuel L., Aguilera, Renato J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219615/
https://www.ncbi.nlm.nih.gov/pubmed/35741451
http://dx.doi.org/10.3390/biology11060930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219615/
https://www.ncbi.nlm.nih.gov/pubmed/35741451
http://dx.doi.org/10.3390/biology11060930

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