Cargando…

Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro

SIMPLE SUMMARY: Despite their documented antitumor effects, thienopyrazole-based compounds remain an underexplored class of molecules. In this study, a screening of 2000 novel molecules revealed a unique thienopyrazole derivative, Tpz-1, that elicited potent and selective programmed cell death in hu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hess, Jessica D., Macias, Luca H., Gutierrez, Denisse A., Moran-Santibanez, Karla, Contreras, Lisett, Medina, Stephanie, Villanueva, Paulina J., Kirken, Robert A., Varela-Ramirez, Armando, Penichet, Manuel L., Aguilera, Renato J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219615/ https://www.ncbi.nlm.nih.gov/pubmed/35741451 http://dx.doi.org/10.3390/biology11060930

Ejemplares similares

Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways
por: Gutierrez, Denisse A., et al.
Publicado: (2022)

Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis
por: Villanueva, Paulina J., et al.
Publicado: (2018)

Synthesis and biological evaluation of thieno[3,2-c]pyrazol-3-amine derivatives as potent glycogen synthase kinase 3β inhibitors for Alzheimer’s disease
por: Yan, Ning, et al.
Publicado: (2022)

Microwave-assisted one pot three-component synthesis of some novel pyrazole scaffolds as potent anticancer agents
por: Gomha, Sobhi M., et al.
Publicado: (2017)

Synthesis and Bioactivity Assessment of Novel Spiro Pyrazole-Oxindole Congeners Exhibiting Potent and Selective in vitro Anticancer Effects
por: Abo-Salem, Heba M., et al.
Publicado: (2020)

A Facile and Convenient Synthesis of some Novel Hydrazones, Schiff’s Base and Pyrazoles Incorporating Thieno[2,3-b]thiophenes
por: Mabkhot, Yahia Nasser, et al.
Publicado: (2011)

Thieno[3,2-b]pyrrole 5-carboxamides as potent and selective inhibitors of Giardia duodenalis
por: Hart, Christopher JS., et al.
Publicado: (2023)

Rapid Shift from SARS-CoV-2 Delta to Omicron Sub-Variants within a Dynamic Southern U.S. Borderplex
por: Robles-Escajeda, Elisa, et al.
Publicado: (2023)

The biological activity of new thieno[2,3-c]pyrazole compounds as anti-oxidants against toxicity of 4-nonylphenol in Clarias gariepinus
por: Sayed, Alaa El-Din H., et al.
Publicado: (2015)

Recent Advances in the Development of Pyrazole Derivatives as Anticancer Agents
por: Zhang, Yingqian, et al.
Publicado: (2023)

Glycophenotype of breast and prostate cancer stem cells treated with thieno[2,3-b]pyridine anticancer compound
por: Mastelić, Angela, et al.
Publicado: (2017)

Synthesis and Anticancer Activities of Pyrazole–Thiadiazole-Based EGFR Inhibitors
por: Kurban, Berkant, et al.
Publicado: (2023)

Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
por: Abdel Reheim, Mohamed A. M., et al.
Publicado: (2017)

Correction to: Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c] pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives
por: Abdel Reheim, Mohamed A. M., et al.
Publicado: (2017)

Biological Validation of Novel Polysubstituted Pyrazole Candidates with in Vitro Anticancer Activities
por: Fahmy, Hoda H., et al.
Publicado: (2016)

Glycosphingolipid expression at breast cancer stem cells after novel thieno[2,3-b]pyridine anticancer compound treatment
por: Marijan, Sandra, et al.
Publicado: (2020)

Potent and Broad-Spectrum Bactericidal Activity of a Nanotechnologically Manipulated Novel Pyrazole
por: Alfei, Silvana, et al.
Publicado: (2022)

Novel family of bis-pyrazole coordination complexes as potent antibacterial and antifungal agents
por: Draoui, Youssef, et al.
Publicado: (2022)

Searching in Mother Nature for Anti-Cancer Activity: Anti-Proliferative and Pro-Apoptotic Effect Elicited by Green Barley on Leukemia/Lymphoma Cells
por: Robles-Escajeda, Elisa, et al.
Publicado: (2013)

Inhibition of protein kinases by anticancer DNA intercalator, 4-butylaminopyrimido[4′,5′:4,5]thieno(2,3-b)quinoline
por: Rohit Kumar, HeggoduG., et al.
Publicado: (2017)

Design, synthesis and anticancer activities evaluation of novel pyrazole modified catalpol derivatives
por: Kong, Yuanfang, et al.
Publicado: (2023)

The Importance of the Pyrazole Scaffold in the Design of Protein Kinases Inhibitors as Targeted Anticancer Therapies
por: Nitulescu, George Mihai, et al.
Publicado: (2023)

2-Phenylthieno[2,3-b]quinoxaline
por: Ramli, Youssef, et al.
Publicado: (2012)

The Anticancer Drug Bleomycin Shows Potent Antifungal Activity by Altering Phospholipid Biosynthesis
por: Pokharel, Mona, et al.
Publicado: (2022)

Author Correction: Glycosphingolipid expression at breast cancer stem cells after novel thieno[2,3-b]pyridine anticancer compound treatment
por: Marijan, Sandra, et al.
Publicado: (2021)

Novel Thieno [2,3-b]pyridine Anticancer Compound Lowers Cancer Stem Cell Fraction Inducing Shift of Lipid to Glucose Metabolism
por: Pervan, Matij, et al.
Publicado: (2022)

Kinase Inhibitory Activities and Molecular Docking of a Novel Series of Anticancer Pyrazole Derivatives
por: Nossier, Eman S., et al.
Publicado: (2018)

Novel Anticancer Fused Pyrazole Derivatives as EGFR and VEGFR-2 Dual TK Inhibitors
por: Saleh, Nashwa M., et al.
Publicado: (2020)

Quantitative and Qualitative Analysis of the Anti-Proliferative Potential of the Pyrazole Scaffold in the Design of Anticancer Agents
por: Nitulescu, George Mihai
Publicado: (2022)

The SARS‐CoV‐2 origin dilemma: Zoonotic transfer or laboratory leak?
por: Ruiz‐Medina, Blanca E., et al.
Publicado: (2021)

The Potent Oxidant Anticancer Activity of Organoiridium Catalysts**
por: Liu, Zhe, et al.
Publicado: (2014)

Development of Advanced Macrosphelides: Potent Anticancer Agents
por: Paek, Seung-Mann
Publicado: (2015)

Larrea tridentata Extract Mitigates Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells
por: Morán-Santibañez, Karla, et al.
Publicado: (2019)

Synthesis and biological evaluation of new derivatives of thieno-thiazole and dihydrothiazolo-thiazole scaffolds integrated with a pyrazoline nucleus as anticancer and multi-targeting kinase inhibitors
por: Othman, Ismail M. M., et al.
Publicado: (2021)

Design, Synthesis and Anticandidal Evaluation of Indazole and Pyrazole Derivatives
por: Rodríguez-Villar, Karen, et al.
Publicado: (2021)

Pyrazole compound BPR1P0034 with potent and selective anti-influenza virus activity
por: Shih, Shin-Ru, et al.
Publicado: (2010)

Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents
por: Alnufaie, Rawan, et al.
Publicado: (2020)

Molecular Modelling Studies on Pyrazole Derivatives for the Design of Potent Rearranged during Transfection Kinase Inhibitors
por: Bhujbal, Swapnil P., et al.
Publicado: (2021)

Discovery of Novel Tetrazoles Featuring a Pyrazole Moiety as Potent and Highly Selective Antifungal Agents
por: Chi, Xiaochen, et al.
Publicado: (2023)

Design, efficient synthesis and molecular docking of some novel thiazolyl-pyrazole derivatives as anticancer agents
por: Sayed, Abdelwahed R., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vkmeb4i19ocrqo7rlampdrvum0