Discovering Novel Small Molecule Compound for Prevention of Monoclonal Antibody Self-Association †

Designing an antibody with the desired affinity to the antigen is challenging, often achieved by lengthening the hydrophobic CDRs, which can lead to aggregation and cause major hindrance to the development of successful biopharmaceutical products. Aggregation can cause immunogenicity, viscosity and...

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Detalles Bibliográficos
Autores principales: Lui, Lok Hin, van der Walle, Christopher F., Brocchini, Steve, Velayudhan, Ajoy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219649/
https://www.ncbi.nlm.nih.gov/pubmed/35735359
http://dx.doi.org/10.3390/antib11020040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219649/
https://www.ncbi.nlm.nih.gov/pubmed/35735359
http://dx.doi.org/10.3390/antib11020040

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