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Discovering Novel Small Molecule Compound for Prevention of Monoclonal Antibody Self-Association †
Designing an antibody with the desired affinity to the antigen is challenging, often achieved by lengthening the hydrophobic CDRs, which can lead to aggregation and cause major hindrance to the development of successful biopharmaceutical products. Aggregation can cause immunogenicity, viscosity and...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219649/ https://www.ncbi.nlm.nih.gov/pubmed/35735359 http://dx.doi.org/10.3390/antib11020040 |