Epigenetic and Transcriptional Signaling in Ewing Sarcoma—Disease Etiology and Therapeutic Opportunities

Ewing sarcoma (EwS), a type of bone and soft tissue tumor, is mainly driven by the expression of the fusion protein EWSR1-FLI1. Upon binding to chromatin, EWSR1-FLI1 reprograms the epigenetic state, alters gene expression, and thus leads to tumorigenesis. Considerable studies have investigated the e...

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Detalles Bibliográficos
Autores principales: Li, Mingli, Chen, Chun-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219675/
https://www.ncbi.nlm.nih.gov/pubmed/35740349
http://dx.doi.org/10.3390/biomedicines10061325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219675/
https://www.ncbi.nlm.nih.gov/pubmed/35740349
http://dx.doi.org/10.3390/biomedicines10061325

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