Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment

Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different amino acid sequences of aberrantly O-glycosylated MUC1, also known as the Tn antigen, expressed in a varie...

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Detalles Bibliográficos
Autores principales: Guerrero-Ochoa, Patricia, Ibáñez-Pérez, Raquel, Berbegal-Pinilla, Germán, Aguilar, Diederich, Marzo, Isabel, Corzana, Francisco, Minjárez-Sáenz, Martha, Macías-León, Javier, Conde, Blanca, Raso, Javier, Hurtado-Guerrero, Ramón, Anel, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219680/
https://www.ncbi.nlm.nih.gov/pubmed/35740244
http://dx.doi.org/10.3390/biomedicines10061223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219680/
https://www.ncbi.nlm.nih.gov/pubmed/35740244
http://dx.doi.org/10.3390/biomedicines10061223

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