Cargando…

Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment

Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different amino acid sequences of aberrantly O-glycosylated MUC1, also known as the Tn antigen, expressed in a varie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guerrero-Ochoa, Patricia, Ibáñez-Pérez, Raquel, Berbegal-Pinilla, Germán, Aguilar, Diederich, Marzo, Isabel, Corzana, Francisco, Minjárez-Sáenz, Martha, Macías-León, Javier, Conde, Blanca, Raso, Javier, Hurtado-Guerrero, Ramón, Anel, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9219680/ https://www.ncbi.nlm.nih.gov/pubmed/35740244 http://dx.doi.org/10.3390/biomedicines10061223

Ejemplares similares

Production of a Granulysin-Based, Tn-Targeted Cytolytic Immunotoxin Using Pulsed Electric Field Technology
por: Guerrero-Ochoa, Patricia, et al.
Publicado: (2020)

Antibody-Based Immunotoxins for Colorectal Cancer Therapy
por: Sanz, Laura, et al.
Publicado: (2021)

Conjugation of the 9-kDa Isoform of Granulysin with Liposomes Potentiates Its Cytotoxicity
por: Soler-Agesta, Ruth, et al.
Publicado: (2022)

Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody**
por: Martínez-Sáez, Nuria, et al.
Publicado: (2015)

Granulysin expression and granulysin-mediated apoptosis in the peripheral blood of osteoarthritis patients
por: Drvar, Vedrana, et al.
Publicado: (2022)

The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL
por: Beatson, Richard, et al.
Publicado: (2015)

Use of the Human Granulysin Transgenic Mice To Evaluate the Role of Granulysin Expression by CD8 T Cells in Immunity To Mycobacterium tuberculosis
por: Thakur, Preeti, et al.
Publicado: (2022)

Comparative Antimicrobial Activity of Granulysin against Bacterial Biothreat Agents
por: Endsley, Janice J, et al.
Publicado: (2009)

Antimicrobial Properties of an Immunomodulator - 15 kDa Human Granulysin
por: Wei, Hung-Mu, et al.
Publicado: (2016)

Nanobody-Based EGFR-Targeting Immunotoxins for Colorectal Cancer Treatment
por: Narbona, Javier, et al.
Publicado: (2023)

Cell Death Mechanisms at the Maternal-Fetal Interface: Insights into the Role of Granulysin
por: Veljkovic Vujaklija, Danijela, et al.
Publicado: (2012)

Contributions of IFN-γ and granulysin to the clearance of Plasmodium yoelii blood stage
por: Hojo-Souza, Natália Satchiko, et al.
Publicado: (2020)

Mucin architecture behind the immune response: design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment
por: Martínez-Sáez, Nuria, et al.
Publicado: (2016)

Immunotoxins: experimental design
por: Dall, P, et al.
Publicado: (2001)

Immunotoxins: The Role of the Toxin (†)
por: Antignani, Antonella, et al.
Publicado: (2013)

Countering immunotoxin immunogenicity
por: Flavell, David J
Publicado: (2016)

Perforin enhances the granulysin-induced lysis of Listeria innocua in human dendritic cells
por: Walch, Michael, et al.
Publicado: (2007)

Expression, processing and transcriptional regulation of granulysin in short-term activated human lymphocytes
por: Latinovic-Golic, Sonja, et al.
Publicado: (2007)

Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays
por: Won, Ha-Kyeong, et al.
Publicado: (2014)

Granulysin, a novel marker for extranodal NK/T cell lymphoma, nasal type
por: Lo Bello, Giuseppe, et al.
Publicado: (2018)

Targeted antigen delivery by an anti-class II MHC VHH elicits focused αMUC1(Tn) immunity
por: Fang, Tao, et al.
Publicado: (2017)

Molecular basis for bacterial N-glycosylation by a soluble HMW1C-like N-glycosyltransferase
por: Piniello, Beatriz, et al.
Publicado: (2023)

Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy
por: Bokori-Brown, Monika, et al.
Publicado: (2018)

Molecular Recognition of GalNAc in Mucin-Type O-Glycosylation
por: Sanz-Martinez, Ignacio, et al.
Publicado: (2023)

An immunohistochemical study of the granulysin expression of 6 types of proven adverse cutaneous drug reaction
por: Weinborn, Marie, et al.
Publicado: (2014)

Enhanced tuberculosis clearance through the combination treatment with recombinant adenovirus-mediated granulysin delivery
por: Hao, Ling, et al.
Publicado: (2020)

Elevated Granulysin Expression in Cytotoxic Lymphocytes from the Blood and Lesions of Patients with Lichen Planus
por: VIČIĆ, Marijana, et al.
Publicado: (2021)

Treatment of solid tumors with immunotoxins
por: Messmer, Davorka, et al.
Publicado: (2005)

Bouganin, an Attractive Weapon for Immunotoxins
por: Bortolotti, Massimo, et al.
Publicado: (2018)

Immunotoxin Therapy for Lung Cancer
por: Xie, Li-Yi, et al.
Publicado: (2017)

Calorimetric Analysis of the Interplay between Synthetic Tn Antigen-Presenting MUC1 Glycopeptides and Human Macrophage Galactose-Type Lectin
por: Beckwith, Donella M., et al.
Publicado: (2021)

Granulysin-Expressing CD4(+) T Cells as Candidate Immune Marker for Tuberculosis during Childhood and Adolescence
por: Mueller, Henrik, et al.
Publicado: (2011)

Granulysin expressed in a humanized mouse model induces apoptotic cell death and suppresses tumorigenicity
por: Hsiao, Ya-Wen, et al.
Publicado: (2016)

Gran1: A Granulysin-Derived Peptide with Potent Activity against Intracellular Mycobacterium tuberculosis
por: Noschka, Reiner, et al.
Publicado: (2021)

Improved Purification of Human Granzyme A/B and Granulysin Using a Mammalian Expression System
por: Rasi, Valerio, et al.
Publicado: (2022)

Cytotoxins and immunotoxins for cancer therapy : clinical applications /
Publicado: (2005)

Immunotoxins: From Design to Clinical Application
por: Kreitman, Robert J., et al.
Publicado: (2021)

Toxin and Immunotoxin Based Therapeutic Approaches
por: Bortolotti, Massimo, et al.
Publicado: (2022)

Challenges in Antibody Development against Tn and Sialyl-Tn Antigens
por: Loureiro, Liliana R., et al.
Publicado: (2015)

Induction of Granulysin and Perforin Cytolytic Mediator Expression in 10-Week-Old Infants Vaccinated with BCG at Birth
por: Semple, Patricia L., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ht4egmifsefanq3aj2k13tetcu