Computational Development of Inhibitors of Plasmid-Borne Bacterial Dihydrofolate Reductase

Resistance to trimethoprim and other antibiotics targeting dihydrofolate reductase may arise in bacteria harboring an atypical, plasmid-encoded, homotetrameric dihydrofolate reductase, called R67 DHFR. Although developing inhibitors to this enzyme may be expected to be promising drugs to fight trime...

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Detalles Bibliográficos
Autor principal: Silva, Pedro J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220120/
https://www.ncbi.nlm.nih.gov/pubmed/35740185
http://dx.doi.org/10.3390/antibiotics11060779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220120/
https://www.ncbi.nlm.nih.gov/pubmed/35740185
http://dx.doi.org/10.3390/antibiotics11060779

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