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Computational Development of Inhibitors of Plasmid-Borne Bacterial Dihydrofolate Reductase
Resistance to trimethoprim and other antibiotics targeting dihydrofolate reductase may arise in bacteria harboring an atypical, plasmid-encoded, homotetrameric dihydrofolate reductase, called R67 DHFR. Although developing inhibitors to this enzyme may be expected to be promising drugs to fight trime...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220120/ https://www.ncbi.nlm.nih.gov/pubmed/35740185 http://dx.doi.org/10.3390/antibiotics11060779 |