2-Hydroxyglutarate in Acute Myeloid Leukemia: A Journey from Pathogenesis to Therapies

The oncometabolite 2-hydroxyglutarate (2-HG) plays a key role in differentiation blockade and metabolic reprogramming of cancer cells. Approximatively 20–30% of acute myeloid leukemia (AML) cases carry mutations in the isocitrate dehydrogenase (IDH) enzymes, leading to a reduction in the Krebs cycle...

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Detalles Bibliográficos
Autores principales: Raimondi, Vittoria, Ciotti, Giulia, Gottardi, Michele, Ciccarese, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220225/
https://www.ncbi.nlm.nih.gov/pubmed/35740380
http://dx.doi.org/10.3390/biomedicines10061359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220225/
https://www.ncbi.nlm.nih.gov/pubmed/35740380
http://dx.doi.org/10.3390/biomedicines10061359

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