An Integrative Analysis of DNA Methylation Pattern in Myotonic Dystrophy Type 1 Samples Reveals a Distinct DNA Methylation Profile between Tissues and a Novel Muscle-Associated Epigenetic Dysregulation

Myotonic dystrophy type 1 (DM1) is a progressive, non-treatable, multi-systemic disorder. To investigate the contribution of epigenetics to the complexity of DM1, we compared DNA methylation profiles of four annotated CpG islands (CpGis) in the DMPK locus and neighbouring genes, in distinct DM1 tiss...

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Detalles Bibliográficos
Autores principales: Koehorst, Emma, Odria, Renato, Capó, Júlia, Núñez-Manchón, Judit, Arbex, Andrea, Almendrote, Miriam, Linares-Pardo, Ian, Natera-de Benito, Daniel, Saez, Verónica, Nascimento, Andrés, Ortez, Carlos, Rubio, Miguel Ángel, Díaz-Manera, Jordi, Alonso-Pérez, Jorge, Lucente, Giuseppe, Rodriguez-Palmero, Agustín, Ramos-Fransi, Alba, Martínez-Piñeiro, Alicia, Nogales-Gadea, Gisela, Suelves, Mònica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220235/
https://www.ncbi.nlm.nih.gov/pubmed/35740394
http://dx.doi.org/10.3390/biomedicines10061372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220235/
https://www.ncbi.nlm.nih.gov/pubmed/35740394
http://dx.doi.org/10.3390/biomedicines10061372

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