Modulation of the 20S Proteasome Activity by Porphyrin Derivatives Is Steered through Their Charge Distribution

Cationic porphyrins exhibit an amazing variety of binding modes and inhibition mechanisms of 20S proteasome. Depending on the spatial distribution of their electrostatic charges, they can occupy different sites on α rings of 20S proteasome by exploiting the structural code responsible for the intera...

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Detalles Bibliográficos
Autores principales: Persico, Marco, Santoro, Anna Maria, D’Urso, Alessandro, Milardi, Danilo, Purrello, Roberto, Cunsolo, Alessandra, Gobbo, Marina, Fattorusso, Roberto, Diana, Donatella, Stefanelli, Manuela, Tundo, Grazia R., Sbardella, Diego, Coletta, Massimo, Fattorusso, Caterina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220251/
https://www.ncbi.nlm.nih.gov/pubmed/35740865
http://dx.doi.org/10.3390/biom12060741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220251/
https://www.ncbi.nlm.nih.gov/pubmed/35740865
http://dx.doi.org/10.3390/biom12060741

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