Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation

Loss-of-function (LOF) variants in SCN1B, encoding the voltage-gated sodium channel β1/β1B subunits, are linked to neurological and cardiovascular diseases. Scn1b-null mice have spontaneous seizures and ventricular arrhythmias and die by approximately 21 days after birth. β1/β1B Subunits play critic...

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Detalles Bibliográficos
Autores principales: Ramos-Mondragon, Roberto, Edokobi, Nnamdi, Hodges, Samantha L., Wang, Shuyun, Bouza, Alexandra A., Canugovi, Chandrika, Scheuing, Caroline, Juratli, Lena, Abel, William R., Noujaim, Sami F., Madamanchi, Nageswara R., Runge, Marschall S., Lopez-Santiago, Luis F., Isom, Lori L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220823/
https://www.ncbi.nlm.nih.gov/pubmed/35603785
http://dx.doi.org/10.1172/jci.insight.152050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220823/
https://www.ncbi.nlm.nih.gov/pubmed/35603785
http://dx.doi.org/10.1172/jci.insight.152050

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