Blimp-1 molds the epigenetic architecture of IL-21–mediated autoimmune diseases through an autoregulatory circuit

Positive regulatory domain 1 (PRDM1) encodes B lymphocyte–induced maturation protein 1 (BLIMP1), also known as a master regulator of T cell homeostasis. We observed a negative relationship between Blimp-1 and IL-21 based on our previous data that Blimp-1 overexpression in T cells suppresses autoimmu...

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Detalles Bibliográficos
Autores principales: Liu, Yu-Wen, Fu, Shin-Huei, Chien, Ming-Wei, Hsu, Chao-Yuan, Lin, Ming-Hong, Dong, Jia-Ling, Lu, Rita Jui-Hsien, Lee, Yi-Jing, Chen, Pao-Yang, Wang, Chih-Hung, Sytwu, Huey-Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220827/
https://www.ncbi.nlm.nih.gov/pubmed/35503415
http://dx.doi.org/10.1172/jci.insight.151614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220827/
https://www.ncbi.nlm.nih.gov/pubmed/35503415
http://dx.doi.org/10.1172/jci.insight.151614

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