Strong off-target antibody reactivity to malarial antigens induced by RTS,S/AS01E vaccination is associated with protection

The RTS,S/AS01E vaccine targets the circumsporozoite protein (CSP) of the Plasmodium falciparum (P. falciparum) parasite. Protein microarrays were used to measure levels of IgG against 1000 P. falciparum antigens in 2138 infants (age 6–12 weeks) and children (age 5–17 months) from 6 African sites of...

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Detalles Bibliográficos
Autores principales: Macià, Dídac, Campo, Joseph J., Moncunill, Gemma, Jairoce, Chenjerai, Nhabomba, Augusto J., Mpina, Maximilian, Sorgho, Hermann, Dosoo, David, Traore, Ousmane, Kusi, Kwadwo Asamoah, Williams, Nana Aba, Oberai, Amit, Randall, Arlo, Sanz, Hèctor, Valim, Clarissa, Asante, Kwaku Poku, Owusu-Agyei, Seth, Tinto, Halidou, Agnandji, Selidji Todagbe, Kariuki, Simon, Gyan, Ben, Daubenberger, Claudia, Mordmüller, Benjamin, Petrone, Paula, Dobaño, Carlota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220828/
https://www.ncbi.nlm.nih.gov/pubmed/35446785
http://dx.doi.org/10.1172/jci.insight.158030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220828/
https://www.ncbi.nlm.nih.gov/pubmed/35446785
http://dx.doi.org/10.1172/jci.insight.158030

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