Early Forms of α-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease

Idiopathic Parkinson’s disease (iPD) is characterized by degeneration of the dopaminergic substantia nigra pars compacta (SNc), typically in the presence of Lewy pathology (LP) and mitochondrial respiratory complex I (CI) deficiency. LP is driven by α-synuclein aggregation, morphologically evolving...

Descripción completa

Detalles Bibliográficos
Autores principales: Flønes, Irene Hana, Nyland, Harald, Sandnes, Dagny-Ann, Alves, Guido Werner, Tysnes, Ole-Bjørn, Tzoulis, Charalampos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220830/
https://www.ncbi.nlm.nih.gov/pubmed/35740871
http://dx.doi.org/10.3390/biom12060747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220830/
https://www.ncbi.nlm.nih.gov/pubmed/35740871
http://dx.doi.org/10.3390/biom12060747

Ejemplares similares