Multiple Components of Protein Homeostasis Pathway Can Be Targeted to Produce Drug Synergies with VCP Inhibitors in Ovarian Cancer

SIMPLE SUMMARY: The increased dependency of cancer cells on protein homeostasis creates a vulnerability that can be exploited using protein homeostasis inhibiting drugs. Recently, valosin-containing protein has emerged as a key component of the pathway and a novel therapeutic target for cancer treat...

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Detalles Bibliográficos
Autores principales: Bastola, Prabhakar, Leiserowitz, Gary S., Chien, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220887/
https://www.ncbi.nlm.nih.gov/pubmed/35740614
http://dx.doi.org/10.3390/cancers14122949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220887/
https://www.ncbi.nlm.nih.gov/pubmed/35740614
http://dx.doi.org/10.3390/cancers14122949

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