Genome-wide studies reveal factors associated with circulating uromodulin and its relationships to complex diseases

Uromodulin (UMOD) is a major risk gene for monogenic and complex forms of kidney disease. The encoded kidney-specific protein uromodulin is highly abundant in urine and related to chronic kidney disease, hypertension, and pathogen defense. To gain insights into potential systemic roles, we performed...

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Detalles Bibliográficos
Autores principales: Li, Yong, Cheng, Yurong, Consolato, Francesco, Schiano, Guglielmo, Chong, Michael R., Pietzner, Maik, Nguyen, Ngoc Quynh H., Scherer, Nora, Biggs, Mary L., Kleber, Marcus E., Haug, Stefan, Göçmen, Burulça, Pigeyre, Marie, Sekula, Peggy, Steinbrenner, Inga, Schlosser, Pascal, Joseph, Christina B., Brody, Jennifer A., Grams, Morgan E., Hayward, Caroline, Schultheiss, Ulla T., Krämer, Bernhard K., Kronenberg, Florian, Peters, Annette, Seissler, Jochen, Steubl, Dominik, Then, Cornelia, Wuttke, Matthias, März, Winfried, Eckardt, Kai-Uwe, Gieger, Christian, Boerwinkle, Eric, Psaty, Bruce M., Coresh, Josef, Oefner, Peter J., Pare, Guillaume, Langenberg, Claudia, Scherberich, Jürgen E., Yu, Bing, Akilesh, Shreeram, Devuyst, Olivier, Rampoldi, Luca, Köttgen, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220927/
https://www.ncbi.nlm.nih.gov/pubmed/35446786
http://dx.doi.org/10.1172/jci.insight.157035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220927/
https://www.ncbi.nlm.nih.gov/pubmed/35446786
http://dx.doi.org/10.1172/jci.insight.157035

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