Nonretinoid chaperones improve rhodopsin homeostasis in a mouse model of retinitis pigmentosa

Rhodopsin-associated (RHO-associated) retinitis pigmentosa (RP) is a progressive retinal disease that currently has no cure. RHO protein misfolding leads to disturbed proteostasis and the death of rod photoreceptors, resulting in decreased vision. We previously identified nonretinoid chaperones of R...

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Detalles Bibliográficos
Autores principales: Vats, Abhishek, Xi, Yibo, Feng, Bing, Clinger, Owen D., St. Leger, Anthony J., Liu, Xujie, Ghosh, Archisha, Dermond, Chase D., Lathrop, Kira L., Tochtrop, Gregory P., Picaud, Serge, Chen, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220944/
https://www.ncbi.nlm.nih.gov/pubmed/35472194
http://dx.doi.org/10.1172/jci.insight.153717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220944/
https://www.ncbi.nlm.nih.gov/pubmed/35472194
http://dx.doi.org/10.1172/jci.insight.153717

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