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Nonretinoid chaperones improve rhodopsin homeostasis in a mouse model of retinitis pigmentosa
Rhodopsin-associated (RHO-associated) retinitis pigmentosa (RP) is a progressive retinal disease that currently has no cure. RHO protein misfolding leads to disturbed proteostasis and the death of rod photoreceptors, resulting in decreased vision. We previously identified nonretinoid chaperones of R...
Autores principales: | Vats, Abhishek, Xi, Yibo, Feng, Bing, Clinger, Owen D., St. Leger, Anthony J., Liu, Xujie, Ghosh, Archisha, Dermond, Chase D., Lathrop, Kira L., Tochtrop, Gregory P., Picaud, Serge, Chen, Yuanyuan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220944/ https://www.ncbi.nlm.nih.gov/pubmed/35472194 http://dx.doi.org/10.1172/jci.insight.153717 |
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