α-Ketoglutarate-Mediated DNA Demethylation Sustains T-Acute Lymphoblastic Leukemia upon TCA Cycle Targeting

SIMPLE SUMMARY: A promising anti-cancer strategy is to target the tumor’s dependence on particular nutrients. However, resistance to single-agent treatment is common due to the adaptability of cancer cells. This research seeks to understand how T acute lymphoblastic leukemia (T-ALL) escapes disrupti...

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Detalles Bibliográficos
Autores principales: Wang, Yanwu, Shen, Ning, Spurlin, Gervase, Korm, Sovannarith, Huang, Sarah, Anderson, Nicole M., Huiting, Leah N., Liu, Hudan, Feng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221025/
https://www.ncbi.nlm.nih.gov/pubmed/35740646
http://dx.doi.org/10.3390/cancers14122983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221025/
https://www.ncbi.nlm.nih.gov/pubmed/35740646
http://dx.doi.org/10.3390/cancers14122983

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