Multiple Mechanisms of NOTCH1 Activation in Chronic Lymphocytic Leukemia: NOTCH1 Mutations and Beyond

SIMPLE SUMMARY: Mutations of the NOTCH1 gene are a validated prognostic marker in chronic lymphocytic leukemia and a potential predictive marker for anti-CD20-based therapies. At present, the most frequent pathological alteration of the NOTCH1 gene is due to somatic genetic mutations, which have a m...

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Detalles Bibliográficos
Autores principales: Pozzo, Federico, Bittolo, Tamara, Tissino, Erika, Zucchetto, Antonella, Bomben, Riccardo, Polcik, Laura, Dannewitz Prosseda, Svenja, Hartmann, Tanja Nicole, Gattei, Valter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221163/
https://www.ncbi.nlm.nih.gov/pubmed/35740661
http://dx.doi.org/10.3390/cancers14122997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221163/
https://www.ncbi.nlm.nih.gov/pubmed/35740661
http://dx.doi.org/10.3390/cancers14122997

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