Minigene Splicing Assays Identify 20 Spliceogenic Variants of the Breast/Ovarian Cancer Susceptibility Gene RAD51C

SIMPLE SUMMARY: Loss-of-function variants of the RAD51C gene are known to confer a risk of breast and ovarian cancers. In this study, we analyzed the impact of RAD51C variants on splicing, a highly regulated gene expression step by which introns are removed and exons are sequentially joined. Exon re...

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Detalles Bibliográficos
Autores principales: Sanoguera-Miralles, Lara, Bueno-Martínez, Elena, Valenzuela-Palomo, Alberto, Esteban-Sánchez, Ada, Llinares-Burguet, Inés, Pérez-Segura, Pedro, García-Álvarez, Alicia, de la Hoya, Miguel, Velasco-Sampedro, Eladio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221245/
https://www.ncbi.nlm.nih.gov/pubmed/35740625
http://dx.doi.org/10.3390/cancers14122960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221245/
https://www.ncbi.nlm.nih.gov/pubmed/35740625
http://dx.doi.org/10.3390/cancers14122960

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