Targeting the Cation-Chloride Co-Transporter NKCC1 to Re-Establish GABAergic Inhibition and an Appropriate Excitatory/Inhibitory Balance in Selective Neuronal Circuits: A Novel Approach for the Treatment of Alzheimer’s Disease

GABA, the main inhibitory neurotransmitter in the adult brain, depolarizes and excites immature neurons because of an initially higher intracellular chloride concentration [Cl(−)]i due to the delayed expression of the chloride exporter KCC2 at birth. Depolarization-induced calcium rise via NMDA rece...

Descripción completa

Detalles Bibliográficos
Autores principales: Capsoni, Simona, Arisi, Ivan, Malerba, Francesca, D’Onofrio, Mara, Cattaneo, Antonino, Cherubini, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221351/
https://www.ncbi.nlm.nih.gov/pubmed/35741668
http://dx.doi.org/10.3390/brainsci12060783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221351/
https://www.ncbi.nlm.nih.gov/pubmed/35741668
http://dx.doi.org/10.3390/brainsci12060783

Ejemplares similares