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Targeting the Cation-Chloride Co-Transporter NKCC1 to Re-Establish GABAergic Inhibition and an Appropriate Excitatory/Inhibitory Balance in Selective Neuronal Circuits: A Novel Approach for the Treatment of Alzheimer’s Disease

GABA, the main inhibitory neurotransmitter in the adult brain, depolarizes and excites immature neurons because of an initially higher intracellular chloride concentration [Cl(−)]i due to the delayed expression of the chloride exporter KCC2 at birth. Depolarization-induced calcium rise via NMDA rece...

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Detalles Bibliográficos
Autores principales:	Capsoni, Simona, Arisi, Ivan, Malerba, Francesca, D’Onofrio, Mara, Cattaneo, Antonino, Cherubini, Enrico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221351/ https://www.ncbi.nlm.nih.gov/pubmed/35741668 http://dx.doi.org/10.3390/brainsci12060783

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